Dr. Brown is a recognized expert in the field of molecular physiology and pharmacology of ion channels and their clinical relevance for cardiac drug safety. His lab was the first to identify the hERG potassium channel as the unintended target for the cardiotoxic effects of Seldane, a blockbuster non-sedating antihistamine, and Propulsid, a blockbuster pro-kinetic, both of which were subsequently withdrawn from the market.  Subsequent work in his laboratory led to the discovery of hERG trafficking inhibition by drugs that may cause sudden cardiac death.